What does peripheral blood stem cell (PBSC) donation involve?

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On each of the four days before you donate, you will receive injections of granulocyte colony-stimulating factor (G-CSF). This is a naturally occurring hormone that increases the number of stem cells your body produces.

You’ll then come to one of our collection centres (in London, Oxford, Sheffield or Manchester), where a doctor will insert a tiny tube in your arm, draw out your blood, and pass it through a machine to collect the stem cells.

Donating only takes 4-5 hours for most people. At the end, a nurse will check how many stem cells you’ve donated. There is a chance that you’ll be asked to come back the next day to donate more.

You won’t need a general anaesthetic or to stay in hospital overnight.

How will I donate my blood stem cells?

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You can donate your stem cells in two ways – through peripheral blood stem cell (PBSC) collection or bone marrow donation. Around 90% of people donate via PBSC collection. However, in some situations and for some conditions, a patient will need stem cells from bone marrow.

If you join our register, you must be willing to donate in either way.

If I join the register will you definitely ask me to donate?

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The majority of people on our register never donate. Once you are on the register you have a 1 in 800 chance of being asked to donate in the next five years.

But your chance of being chosen to donate depends on your age and sex. A young man aged 16–30 has a 1 in 200 chance of being chosen to donate in the next five years.

We’ll only ask you to donate if you have a similar tissue type to someone in desperate need of a transplant.

If you’re a match and refuse, it could be devastating news for someone with a life-threatening illness. That’s why we ask you to be fully committed when you sign up.

Do I need to join more than one register?

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No, you only need to join one stem cell bone marrow register. All potential donors in the UK are added to a single registry managed by Anthony Nolan. Joining more than one would cause duplication and waste valuable resources.

Is there more than one bone marrow register in the UK?

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Anthony Nolan, The British Bone Marrow Register (operated by NHS Blood & Transplant), The Welsh Bone Marrow Donor Registry (operated by the Welsh Blood Service) and DKMS UK all recruit donors in the UK.

All these organisations add their donors to a single UK registry, the Anthony Nolan and NHS Stem Cell Registry, which Anthony Nolan manages.

What happens to my sample after you take it?

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They'll come back to Anthony Nolan and we find out your 'tissue type' in order to add your details to our register. Then every time someone needs a transplant, we'll compare their tissue type to yours - and to people on our register and registers across the world.

To find out more about how we work out your tissue type, head to The Science Behind Our Work.

Why do you sign people up to the register using swabs?

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We have changed the way we collect donor’s tissue type from taking blood samples, to taking spit samples, to now asking people to do a cheek swab to join the stem cell register.

Whichever method you sign up by, you’ll be on our register in exactly the same way and ready to potentially save someone's life. If you signed up before then there’s no need to sign up again.

Does it cost to join the register?

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No, it won’t cost you anything. It does cost us £40 to put each person on our register, though. And that’s why we continue to raise funds, so we can continue to grow our register.

If you’re a match and come to one of our collection centres in London, Oxford, Sheffield or Manchester to donate, we’ll pay all your expenses, including travel, hotel, food and loss of earnings.