What does a bone marrow transplant involve?

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If you need to give cells from your bone marrow (found inside your large bones), doctors will give you a general anaesthetic and draw the cells from your pelvis using a sterile needle and syringe.

You will need to stay in hospital for two nights if you donate bone marrow.

What does peripheral blood stem cell (PBSC) donation involve?

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On each of the four days before you donate, you will receive injections of granulocyte colony-stimulating factor (G-CSF). This is a naturally occurring hormone that increases the number of stem cells your body produces.

You’ll then come to one of our collection centres (in London, Oxford, Sheffield or Manchester), where a doctor will insert a tiny tube in your arm, draw out your blood, and pass it through a machine to collect the stem cells.

Donating only takes 4-5 hours for most people. At the end, a nurse will check how many stem cells you’ve donated. There is a chance that you’ll be asked to come back the next day to donate more.

You won’t need a general anaesthetic or to stay in hospital overnight.

How will I donate my blood stem cells?

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You can donate your stem cells in two ways – through peripheral blood stem cell (PBSC) collection or bone marrow donation. Around 90% of people donate via PBSC collection. However, in some situations and for some conditions, a patient will need stem cells from bone marrow.

If you join our register, you must be willing to donate in either way.

If I join the register will you definitely ask me to donate?

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The majority of people on our register never donate. Once you are on the register you have a 1 in 800 chance of being asked to donate in the next five years.

But your chance of being chosen to donate depends on your age and sex. A young man aged 16–30 has a 1 in 200 chance of being chosen to donate in the next five years.

We’ll only ask you to donate if you have a similar tissue type to someone in desperate need of a transplant.

If you’re a match and refuse, it could be devastating news for someone with a life-threatening illness. That’s why we ask you to be fully committed when you sign up.

Do I need to join more than one register?

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No, you only need to join one stem cell bone marrow register. All potential donors in the UK are added to a single registry managed by Anthony Nolan. Joining more than one would cause duplication and waste valuable resources.

Is there more than one bone marrow register in the UK?

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Anthony Nolan, The British Bone Marrow Register (operated by NHS Blood & Transplant), The Welsh Bone Marrow Donor Registry (operated by the Welsh Blood Service) and DKMS UK all recruit donors in the UK.

All these organisations add their donors to a single UK registry, the Anthony Nolan and NHS Stem Cell Registry, which Anthony Nolan manages.

What happens to my sample after you take it?

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They'll come back to Anthony Nolan and we find out your 'tissue type' in order to add your details to our register. Then every time someone needs a transplant, we'll compare their tissue type to yours - and to people on our register and registers across the world.

To find out more about how we work out your tissue type, head to The Science Behind Our Work.