Ryan donated via bone marrow in 2020 and shared his story

Donating via Bone Marrow

To help you know what to expect when donating stem cells through your bone marrow, this page has the key things to remember.

What’s on this page?

What is a bone marrow donation? 

A bone marrow donation is where stem cells are collected directly from the bone marrow in your hip bone while you’re under a general anaesthetic.  

This method is less common and is used in 10% of all donations.

How does it work?

As our donation animation shows, donating stem cells through your bone marrow is a straightforward procedure. Here are the steps you can expect: 

What to expect before your donation: 

On the day before your donation, you will travel to the Collection Centre. You will spend the night there ready to have the procedure the following morning. If you are bringing a companion they will stay at a hotel nearby that we can organise for you should it be required. 

How does the donation work: 

Before the procedure starts, you’ll be put under a general anaesthetic that means you won’t feel or remember anything about the donation. The procedure itself involves inserting a needle into your hip bone to collect blood enriched in stem cells and takes about 30 minutes.  

After the procedure, you’ll wake up on a ward with some small puncture wounds in your hip - your body will be busy replenishing the stem cells already. You’ll stay one more night in the Collection Centre for observations and then you’ll be discharged the next morning. 

What to expect in your recovery: 

You’ll feel achy in the area where the bone marrow was taken from and have some bruising, as well as feel tired after the general anaesthetic. We recommend taking a week off work (depending on how active your job is) and refraining from physical activity for two weeks.

Our donor follow-up team will contact you to provide our post donation care and ensure you have a full recovery, to find out more about this, please view our post donation care advice page

It’s important that you book a GP appointment a month after your donation for a blood test to check your blood counts are as expected. Our Donor Follow-up Team will help you with this. 

Organising your medical and donation

Your Donor Provision Coordinator will arrange everything for your medical and donation, including transport and accommodation.  

When will you donate? 

Your coordinator will let you know the dates the patient’s hospital have requested in line with the patient’s treatment. These requested dates are what is ideal for the hospital, but they’re not set in stone and can be moved to suit your availability too.  

You’ll be booked in at the Collection Centre in the weeks leading up to your donation for your medical, and a two night stay for your donation.

Your medical and donation will happen at the same collection centre, with the medical usually being 2-4 weeks before the donation. The medical should take around 2-3 hours, during which time you will have an ECG, a COVID test, a blood draw and be asked to provide a urine sample. You will also be counselled for the procedure, be asked about your general health, any family health history and be asked to sign the consent forms.

If you have any questions, please contact your coordinator.

Where do you donate? 

We try and find the most convenient Collection Centre for where you live, and your Donor Provision Coordinator will chat through the locations that are available for the proposed dates. 

We currently have Collection Centres in London, at the London Clinic in Marylebone, UCH in Euston and King’s in south London, as well as in Sheffield, Manchester and Oxford.  

Please note: We cannot guarantee a booking at your preferred hospital.

Travelling to your donation 

We cover all travel costs for you and a companion. We will also provide a hotel close to the Collection Centre for your companion. Any travel or food costs you have can be reimbursed in line with our policy. Find out more about our donor expenses.

Precautions to take ahead of your donation

If you are feeling unwell

Provision Coordinator know as soon as possible, if it is an emergency and out of hours please call 07710 599161.

Sexually Transmitted Infections (STIs)

If you’re sexually active, particularly with a new partner or more than one partners, please take extra precautions to prevent any risk of contracting an STI.

If you become sexually active with a new partner in between your medical and donation, please inform us.

If an undiagnosed infection is transmitted to the patient, it could have serious consequences for them. The NHS has lots of advice on safer sex:  https://www.nhs.uk/live-well/sexual-health/sex-activities-and-risk/


If you’re sexually active, please use a reliable form of contraception until after your donation. Pregnant donors are not able to go ahead with their donation as this could be a risk to the baby.

A note on Hep E

Over the last few years there has been a rise in the number of people acquiring Hepatitis E in the UK. Most healthy people are symptomless, and the infection clears by itself, but it can be very risky if transmitted to a patient. 

The most common way for people to catch Hepatitis E is through eating raw or undercooked meat (especially pork products) and shellfish, so from now until after your donation, please be very careful with what you eat.

Kit list: Things to pack for overnight hospital stay

Items to consider:

  • Blanket and pillow (provided by the hospital but feel free to bring your own if you have a preference).
  • Clothes - pajamas, underwear, socks, dressing gown, outfit to go home in.
  • Earplugs.
  • Entertainment - mobile, laptop, book, buds, headphones.
  • Glasses/contact lenses.
  • Personal medications.
  • Phone charger/cable.
  • Slippers.
  • Snacks.
  • Toiletries - toothbrush, hairbrush, toothpaste, skincare, sleep mask, shampoo, conditioner, face towel, wet wipes and deodorant.

Being asked to donate again

After donating BM you may be asked to consider donating a second time to the patient. This happens in approximately 10% of cases and it could be months or years after your donation, but it is usually within the first year. You could be asked to donate BM again or via a different kind of white blood cell called lymphocytes.

Resources for the donor journey


If you have any questions or concerns, don’t hesitate to contact your Donor Provision Coordinator at Anthony Nolan.  

Real life donor stories

You can read more donor stories on our blog.

Donor Asanka - bone marrow donation

They told me that the patient actually needed bone marrow, rather than [stem cells through the bloodstream]. I didn’t really have any doubts or nerves through the process. I was happy to do it whatever way was best for the patient.

Everyone was really lovely and the hospital was really nice. After the procedure was the worst part. I wasn’t really expecting to feel as bad as I did….They took out the maximum that they were allowed to take - and they warned me that there would be some side effects. I was off work, but Anthony Nolan had covered my salary - so it was okay.

Asanka, bone marrow donor