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1. Cord blood transplant immune reconstitution study
This study aims to investigate the speed and diversity of recovery of all the different cells in the immune system after a cord blood transplant. This is important as it will help us to predict and treat the complications (especially infection) which are common after these types of transplants.
Type of study: Multi-centre
Number of patients: All cord blood transplant recipients in the UK (three years). 150-200 patients
Principal/Chief Investigator: Shaw/Madrigal/Navarette
Sponsor: Anthony Nolan/NHSBT
Funding: Anthony Nolan/NHSBT
Staff: Shaw/Madrigal/Ahyee
Outcomes: EBMT abstract (submitted)
2. Patient/donor project
The aim of this study is to understand the impact of genetic factors on the outcome and complications of stem cell transplantation.
Samples are processed and stored in pairs with unique numbers (de-identified). We have developed a large and comprehensive Biobank and performed extensive analysis both internally and as part of larger collaborations. We have done extensive analysis of HLA and especially the clinical impact of HLA-DPB1. In addition we have studied other immune response genes and systems such as KIR, NOD2/CARD15, TGF-beta, TNF-alpha, IL12 and Caspase 8.
Type of study: Multi-centre
Number of patients: All unrelated donor transplant recipients in the UK receiving a transplant from an Anthony Nolan donor.
Long-standing study (>10 years) >2000 pairs included to data.
Principal/Chief Investigator: Madrigal/Marsh/Shaw
Sponsor: Anthony Nolan
Funding: Anthony Nolan
Staff: Madrigal/Marsh/Shaw/Mayor/Schellekens/
Outcomes: Numerous presentations and publications. Several PhDs (see website)
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