Our Clinical Research Group studies the impact of different genetic markers on the clinical outcome of patients following haematopoietic stem cell transplants.
The group aims to provide the essential link between:
- Understanding genetic information.
- Interpreting it in the context of patients’ clinical information.
- ‘Translating’ this into changes/improvements in practice in the patient setting.
One area we focus on is reducing the risk of disease relapse after transplant. We have identified donor factors to help us choose the most appropriate donor based on their genetic tests.
The results of our studies allow us to undertake translational research projects, which put what we have learned into practice. These have both a clinical and laboratory focus.
The Clinical Research Group has a number of important links:
- Pulsipher M.A., Chitphakdithai P., Logan B.R., Shaw B.E., Wingard J.R., Lazarus H.M., Waller E.K., Seftel M., Stroncek D.F., Lopez A.M., Maharaj D., Hematti P., O'Donnell P.V., Loren A.W., Leitman S.F., Anderlini P., Goldstein S.C., Levine J.E., Navarro W.H., Miller J.P. and Confer D.L.: Acute toxicities of unrelated bone marrow versus peripheral blood stem cell donation: results of a prospective trial from the National Marrow Donor Program. Blood, 121: 197-206, 2013.
- Fleischhauer K., Shaw B.E., Gooley T., Malkki M., Bardy P., Bignon J.D., Dubois V., Horowitz M.M., Madrigal J.A., Morishima Y., Oudshoorn M., Ringden O., Spellman S., Velardi A., Zino E. and Petersdorf E.W.: Effect of T-cell-epitope matching at HLA-DPB1 in recipients of unrelated-donor haemopoietic-cell transplantation: a retrospective study. Lancet Oncology, 13: 366-74, 2012.
- Boo M., van Walraven S.M., Chapman J., Lindberg B., Schmidt A.H., Shaw B.E., Switzer G.E., Yang E. and Egeland T.: Remuneration of hematopoietic stem cell donors: principles and perspective of the World Marrow Donor Association. Blood, 117: 21-5, 2011.
- Shaw B.E.: First do no harm. Blood, 115: 4978-9, 2010.
- Mayor N.P., Shaw B.E., Hughes D.A., Maldonado-Torres H., Madrigal J.A., Keshav S. and Marsh S.G.E.: Single nucleotide polymorphisms in the NOD2/CARD15 gene are associated with an increased risk of relapse and death for patients with acute leukemia after hematopoietic stem-cell transplantation with unrelated donors. Journal of Clinical Oncology, 25: 4262-9, 2007.