If you're receiving stem cells donated from someone else – a relative, unrelated donor or cord blood – then doctors need to find a donor whose tissue type matches yours.
At Anthony Nolan, we maintain a register of willing volunteers who are ready to donate their stem cells to someone in need of a transplant. We will search for a matching donor, perform the appropriate tests and co-ordinate the stem cells arriving at hospital. For more information on each step of the process, see the links below.
Our leaflet Essential Facts for Stem Cell Transplant Patients has further information.
You – Unsurprisingly you will be tested first so that the search for your match can begin. Someone at your hospital or transplant centre will take a blood sample to do a tissue type test. The results will be passed on to Anthony Nolan so that we can start searching.
Your siblings - If you have any, your brothers or sisters will be tested next. They have the best chance of being a perfect match for you because they share the same parents. Blood samples will be taken by their local doctor/hospital and sent for tissue typing.
Anyone else? - Usually your wider family and friends will not be tested as it’s very unlikely that they will be a match. If they want to help other people in need of a stem cell transplant, then they may be interested in joining the Anthony Nolan register.
Once your transplant centre gets in touch, we search all the possible donors in the UK to find your best match. If necessary, we will look for possible donors on registries from across the world. We can also check for cord blood matches in our cord bank.
'As a member of the Anthony Nolan search team, I'm one of the first cogs in the wheel when a patient requires a transplant.'
Catherine. You can read more about the role of our search team in their blog.
Choosing your donor – the lab will test the samples to find the best match. After all the factors have been considered, such as your HLA tissue type and what’s best for treating your condition, your medical team will select your donor.
Arranging the donation – when your matched donor has been selected, we’ll get in touch and arrange for them to have further blood tests and a full medical to make sure they’re fit and healthy to donate.
Once they donate, we’ll arrange for the stem cells to get from your donor to you as fast as possible. We’ll have a trained and experienced volunteer courier ready to pick the cells up and bring them straight to your transplant centre. This is always done, from anywhere in the world, within 72 hours.
For a transplant to take place, you need to have a donor whose tissue type matches your own. Matching is based on your human leukocyte antigen (HLA) tissue type. Your HLA is part of what makes you ‘you’ – your individual genetic characteristics.
Your HLA type is made up of five genes. Each one of these has two different versions (called alleles) making 10 in total. You inherit one version from your mother and one from your father. When it comes to matching you with a donor, if nine of these genes match up it’s called a 9/10 match. If all 10 match then you’ve got yourself a 10/10 match. It’s important that your doctors find the best possible match because this will give your body the best possible chance of accepting your donor’s stem cells.
We test to see if you are positive for cytomegalovirus (or CMV for short) – a very common virus that often has no side effects. Ideally, we want to find a donor who tests the same for this virus as you do. There is now growing evidence that when a patient and donor have matched CMV status it helps improve transplant success.
Finally, we will consider the age of your donor too. This is because our latest research has confirmed that transplants are generally more successful when younger donors are selected.
If you have an HLA tissue type that’s rare or less common, it may be harder to find a matching donor, because there may be fewer people with your tissue type.
Everyone’s HLA tissue type is inherited, so the best chance of finding a suitable donor could come from someone with the same racial or ethnic background. In the past, it’s been a challenge to find donors for people from black, Asian or other ethnic minority backgrounds, but at Anthony Nolan we’re encouraging more people from these backgrounds to join our stem cell register or donate cord blood.
If a suitable adult donor cannot be found, your transplant team will discuss possible alternatives with you.
Your transplant co-ordinator will be updated on the progress of the search regularly. If there are any difficulties, they’ll let you know. Depending on your condition, you may need additional treatment to help control your symptoms during this time.
While waiting for a transplant some patients, their friends or families decide they’d like to help raise awareness by encouraging people to sign up to the Anthony Nolan register. It could give you something to focus your energy on and help save lives at the same time.
But it’s important to bear in mind that it’s very unlikely to find a matching donor for you or your loved one through your own appeal. This is because there are so many different tissue types in the world. However, there are thousands of new potential donors added to registers around the world every day and your doctors and our search team will be focused on finding you the best possible match.
At Anthony Nolan, we can’t accept requests to find a donor from individual patients or their families. If you live outside of the UK, it’s still possible for us to search our registry but the request must come from your country’s own stem cell / bone marrow registry. Your hospital will be able to contact your country’s registry for you.
We're not a hospital and we can’t organise the transplants ourselves. We don't currently have any financial support programmes for people outside of the United Kingdom.
Information published: 26/04/2018
Next review due: 26/04/2021