Anthony Nolan is fully dedicated to funding research at the Anthony Nolan Research Institute. Led by Professor J Alejandro Madrigal, MD PhD FRCP FRCPath DSc, the Institute aims to improve the outcome of bone marrow transplantation (BMT).
The Institute is solving the three main problems in transplantation: graft-versus-host disease (GvHD), which is caused by differences in human leucocyte antigens (HLA); viral infection; and the separation of GvHD from the effect (GvL).
The Institute has five main aims:
10 years of progress
Over the past 10 years our research team has made significant progress in many areas.
Notably, we have developed a new method to detect molecular differences that might be responsible for graft rejection. We have also identified CMV virus peptides that might be relevant in the future use of vaccinations.
In addition, we are studying the mechanisms of differentiation of the immune response after transplant. This may allow us to treat early stage GvHD.
Teaching and training
One of the Research Institute’s most important activities is academic teaching and training, in partnership with University College London (UCL). Our PhD students are registered with UCL and a number of our staff hold academic positions within the UCL Cancer Institute.
We have structured the Institute so a senior scientist is in charge of each research area and supervises a team of postdoctoral research fellows, PhD students and technicians. The teams often work together, as many of the projects overlap. This allows us to share experiences and facilities.
Find out more about our achievements.
If you have further enquiries, our team is here to help.